Markle lahir dan dibesarkan di Los Angeles, California, dan berasal dari keturunan campuran. Selama masa belajarnya di Northwestern University, dia mulai memainkan peran-peran kecil di serial televisi dan film Amerika Serikat. Dari 2011 sampai 2017, dia memainkan peran yang membuatnya dikenal, Rachel Zane, di serial drama Amerika Serikat SUITS.

FILMOGRAPHY
A LOT LIKE LOVE
REMEMBER ME
GET HIM TO THE GREEK
THE CANDIDATE
HORRIBLE BOSSES
DYSFUNCTIONAL FRIENDS
RANDOM ENCOUNTERS
ANTI-SOCIAL

TELEVISI
GENERAL HOSPITAL
CENTURY CITY
CUTS
LOVE, INC.
1 VS. 100
THE WAR AT HOME
CSI: NY
DECEIT
DEAL OR NO DEAL
GOOD BEHAVIOR
90210
'TIL DEATH
THE APOSTLES
KNIGHT RIDER
WITHOUT A TRACE
FRINGE
THE LEAGUE
CSI: MIAMI
THE BOYS & GIRLS GUIDE TO GETTING DOWN
SUITS
CASTLE
WHEN SPARKS FLY
DATER'S HANDBOOK